Table 1.

The interactions for itraconazole with drugs.

Drug	The Impact of pH on Absorption	Reference
Omeprazole	Decrease of AUC0-24 and Cmax of itraconazole.	[18]
	The Impact of Interaction with CYP on Pharmacokinetic Parameters
Ibrutinib	The inhibition of CYP3A4 by itraconazole results in 10-fold increase of AUC and 8.8-fold increase of Cmax for ibrutinib.	[22]
Efavirenz	The induction of CYP3A4 activity by efavirenz led to decrease of exposure to itraconazole and its metabolite.	[24]
Atorvasatatin	The inhibition of CYP3A4 by itraconazole resulted in the increase in AUC, the peak serum concentration and half-life of atorvastatin lactone.	[26]
Oxycodone	The inhibition of the gut and liver CYP3A4 resulted in the increase in the exposure to oxycodone via inhibition of N-demetylation.	[28]
Midazolam	The inhibition of CYP3A4 by itraconazole resulted in the increase in the concentration of midazolam.	[29]
Alprazolam	The inhibition of CYP3A4 by itraconazole resulted in the increase in AUC and prolongation of half-life of alprazolam and decrease in the oral clearance.	[30]
Haloperidol	Voriconazole increased of AUC of haloperidol for both genetic types—CYP2D6*10/*10 and CYP2D6*1/*1.	[31]
Phenytoin	The inhibition of CYP2C9 by itraconazole increased the AUC of phenytoin by 10%.	[32]