Table 1.

In this table proteins from different DNA damage pathways, which are functioning at G4s, like binding, unwinding, stabilizing, and so forth, are summarized. The organism in which the G4 interaction was shown is listed. The function which is marked with an asterisk (*) is not proven, yet.

Pathway	Protein	Function at G4s	Organism	REFs
HR	EXO1	Binding and unwinding *	Human	[69]
	DNA2	Binding and unwinding	Human/yeast	[67,70]
	Rad50	Binding *	Human	[71,72]
	Rad51	Necessary for G4-mediated DNA damage	Human	[73]
	BRCA1	Binding	Human	[74]
	BRCA2	Necessary for G4-mediated DNA damage	Human	[75]
	Mre11	Binding	Yeast	[66,71]
NHEJ	Ku70	Binding	Human	[76,77,78]
	Ku80	Binding	Human	[76,77]
	PARP3	Affecting G4 levels	Human	[79]
	AID	Binding	Human	[80,81,82]
	PARP1	Binding	Human	[78,83]
BER	OGG1	Supporting formation	Human	[84]
	APE1	Supporting formation	Human	[84,85]
	PARP1	Binding	Human	[78,83]
NER	Rad23	Binding *	Yeast	[86]
	CSB	Binding and resolving	Human	[87]
	XAB2	Binding *	Human	[71]
	XPD	Binding and unwinding	Human	[88]
	XPB	Binding	Human	[88]
	RPA	Binding, preventing formation, unfolding	Human	[68,89,90,91,92]
	DDB2	Binding *	Human	[78]
	Zuo1	Binding and stabilizing	Yeast	[86]
MMR	MutS	Binding	Bacteria	[93,94]
	MutL	Binding	Bacteria	[93]
	MSH2	Binding	Human	[95]
	MSH6	Binding	Human	[95]
	MSH4	Binding *	Human	[78]
	Exo1	Binding and unwinding *	Human	[69]
TLS	Pol η	Replicating past G4s	Human	[96]
	Pol κ	Replicating past G4s	Human	[96]
	REV1	Binding, preventing refolding	Human	[97,98]
	Pol θ	Preventing deletions at G4s	Human	[99]
Helicases	WRN	Unwinding	Human	[71,100,101]
	FANCJ	Unwinding	Human	[39]
	BLM	Binding and unwinding	Human	[61,102]
	Pif1	Binding and unwinding	Yeast	[17,40]