Table 3.
Levels of IL-1β, IL-6, TNF-α, and IL-10 in skin wounds after 3, 7, or 14 days of treatment with vehicle, collagenase cream, or ME0.5.
| Period | Treatment | IL-1β | IL-6 | TNF-α | IL-10 |
|---|---|---|---|---|---|
| 3 days | Vehicle | 1238.00 ± 137.90 | 2083.00 ± 219.00 | 205.50 ± 34.11 | 203.60 ± 66.43 |
| Collagenase | 1176.00 ± 186.60 | 1730.00 ± 264.30 | 202.70 ± 64.39 | 181.70 ± 51.34 | |
| ME0.5 | 1177.00 ± 226.50 | 1505.00 ± 308.10 | 120.10 ± 27.55 | 397.60 ± 158.90 | |
| 7 days | Vehicle | 807.20 ± 165.80 | 1893.00 ± 566.80 | 80.35 ± 27.41 | 144.90 ± 35.17 |
| Collagenase | 579.50 ± 104.80 | 820.80 ± 218.70 * | 45.33 ± 13.75 | 457.50 ± 149.70 | |
| ME0.5 | 266.60 ± 68.05 * | 570.10 ± 98.06 ** | 21.19 ± 4.03 * | 262.30 ± 78.13 | |
| 14 days | Vehicle | 2230.00 ± 254.70 | 1653.00 ± 177.30 | 138.30 ± 40.96 | 217.10 ± 70.60 |
| Collagenase | 1369.00 ± 207.70 * | 1113.00 ± 149.00 | 30.52 ± 8.73 ** | 645.50 ± 156.80 | |
| ME0.5 | 937.40 ± 142.20 *** | 831.70 ± 173.30 ** | 31.58 ± 10.02 ** | 1128.00 ± 161.80 ** |
The results were expressed as pg/mg of protein. ANOVA, Dunnett’s test; * p < 0.05, ** p < 0.01, *** p < 0.001.