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. 2021 Oct 29;13(11):3877. doi: 10.3390/nu13113877

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Arachidonic Acid metabolism via COX-2, CYP450, 5-LOX and 12-LOX. ARA metabolism via COX-2, CYP450, 5-LOX and 12-LOX produces PGE₂, 20-HETE, 5-HETE, and 12-HETE respectively. Only those oxylipins quantified on our platform are illustrated here. Abbreviations: COX-2: cyclooxygenase-2; CYP450: cytochrome P450; 5-LOX: 5-lipoxygenase; 12-LOX: 12-lipoxygenase; PGE₂: prostaglandin E₂; 5-HETE: 5-hydroxyeicosatetraenoic acid; 12-HETE: 12-hydroxyeicosatetraenoic acid.