Table 2.

Odds of characteristics of baseline adenoma by high vs. low concentrations of baseline oxylipins (n = 256) ^a,b.

Category of Oxylipin Metabolite	Advanced n = 126	Size ≥1 cm n = 115	Villous Histology n = 47	Multiplicity n = 50
PGE2 (pg/mL)	OR (95% CI)
1 (0.00–18.0)	Ref	Ref	Ref	Ref
2 (18.1–277.5)	0.55 (0.33–0.92)	0.52 (0.31–0.87)	0.90 (0.47–1.72)	0.78 (0.41–1.48)
20-HETE (pg/mL)
1 (0.0–5.0)	Ref	Ref	Ref	Ref
2 (5.1–20.3)	0.95 (0.57–1.57)	0.97 (0.58–1.61)	1.15 (0.60–2.19)	0.92 (0.49–1.74)
12-HETE (pg/mL)
1 (0.0–24.5)	Ref	Ref	Ref	Ref
2 (24.6–718.7)	0.66 (0.40–1.09)	0. 84 (0.51–1.40)	0.71 (0.37–1.36)	0.80 (0.43–1.51)
5-HETE
1 (0.0–46.6)	Ref	Ref	Ref	Ref
2 (46.7–301.2)	0.53 (0.33–0.94)	0.61 (0.37–1.02)	0.37 (0.19–0.75)	0.88 (0.47–1.67)

^a Categories created by dividing observations as < median vs. ≥ median value for each metabolite; ^b Logistic regression models adjusted for age, sex, and NSAID use. PGE₂: prostaglandin E₂; 20-HETE: 20-hydroxyeicosatetraenoic acid; 12-HETE: 12-hydroxyeicosatetraenoic acid; 5-HETE: 5-hydroxyeicosatetraenoic acid.