Table 4.
Main findings in meta-analyses.
| Outcomes | Summary of Findings | Quality of Evidence (Grade) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pooled Effect Het |
Publication Bias | ||||||||||||||
| K | N | Ns | SMD | 95% CI | I2 (p for Q-test) |
Funnel Plot (p for Egger) |
Trim and Fill | Risk of Bias | Incons | Indirect | Imprec | Pub. Bias |
Quality | ||
| Adj SMD | % of Var | ||||||||||||||
| Impact of FMS Symptoms | 6 | 249 | 41.5 | −0.62 | −0.93 to −0.31 | 5.2% (p = 0.4) | Sym (p = 0.9) | −0.62 | 0% | Medium | No | No | Yes | No | Moderate |
| Pain | 6 | 267 | 44.5 | −0.45 | −0.69 to −0.21 | 0% (p = 0.52) | Asym (p = 0.2) | −0.72 | 28% | Medium | No | No | Yes | Yes | Low |
| Dynamic Balance | 3 | 168 | 56 | −0.76 | −1.12 to −0.39 | 4.4% (p = 0.35) | Sym (p = 0.52) | −0.75 | 0% | Medium | No | No | Yes | No | Low |
| Aerobic Capacity | 5 | 164 | 32.8 | 0.32 | 0.004 to 0.63 | 0% (p = 0.57) | Asym (p = 0.31) | 0.36 | 12% | Medium | No | No | Yes | Yes | Low |
| Fatigue | 4 | 153 | 38.5 | −0.58 | −1.02 to −0.14 | 5.4% (p = 0.37) | Asym (p = 0.09) | −0.48 | 20% | Medium | No | No | Yes | Yes | Low |
| Quality of Life | 5 | 246 | 49.2 | 0.55 | 0.3 to 0.81 | 0% (p = 0.73) | Sym (p = 0.9) | 0.52 | 0% | Medium | No | No | Yes | No | Moderate |
| Anxiety | 3 | 137 | 45.7 | −0.47 | −0.91 to −0.03 | 0% (p = 0.32) | Asym (p =0.2) | −0.57 | 22% | Medium | No | No | Yes | Yes | Very-Low |
| Depression | 4 | 196 | 49 | −0.46 | −0.76 to −0.16 | 4.6% (p = 0.4) | Asym (p =0.14) | −0.52 | 13% | Medium | No | No | Yes | Yes | Low |
Abbreviations: GRADE = grading of recommendations assessment, development, and evaluation, Het = heterogeneity, K = number of comparisons, N = total sample size, Ns = Participants per study, SMD = Cohen’s standardized mean difference, 95% CI = 95% confidence interval, I2 = degree of inconsistency p = p-value; Adj = adjusted, % of var = percentage of variation, Indirect = indirectness, Imprec = imprecision, Pub bias = publication bias, Sym = symmetric, Asym = asymmetric.