Table 2.
Association between inflammatory biomarkers and sarcopenia in older adults with chronic comorbidities, NHANES 1999–2006 (n = 2483).
| Varibales | No. Sarcopenia /Overall |
Prevalence (%) and 95% CI | cOR and 95% CI (n = 2483) |
aOR and 95% CI † (n = 2483) |
aOR and 95% CI § (n = 2483) |
|---|---|---|---|---|---|
| CRP (mg/L) | |||||
| <1.2 | 161/599 | 26.9 (23.5, 30.6) | REF | REF | REF |
| 1.2–2.6 | 151/636 | 23.7 (20.6, 27.2) | 0.85 (0.66 1.10) | 1.02 (0.75, 1.38) | 0.89 (0.61, 1.33) |
| 2.7–5.2 | 141/619 | 22.8 (19.6, 26.3) | 0.80 (0.62, 1.04) | 1.28 (0.93, 1.76) | 1.05 (0.76, 1.46) |
| ≥5.3 | 121/629 | 19.2 (16.3, 22.5) | 0.65 (0.49, 0.87) | 1.29 (0.93, 1.80) | 1.44 (0.95, 2.16) |
| p-trend < 0.01 | p-trend = 0.06 | p-trend = 0.07 | |||
| SII(×109 cells/L) | |||||
| <365.7 | 118/620 | 19.0 (16.1, 22.3) | REF | REF | REF |
| 365.7–503.6 | 109/623 | 17.5 (14.7, 20.7) | 0.90 (0.68, 1.20) | 0.89 (0.64, 1.24) | 0.90 (0.59, 1.37) |
| 503.7–704.0 | 156/619 | 25.2 (21.9, 28.8) | 1.43 (1.09, 1.88) | 1.45 (1.05, 2.01) | 1.36 (0.84, 2.18) |
| ≥704.1 | 191/621 | 30.8 (27.2, 34.5) | 1.89 (1.45, 2.46) | 1.90 (1.38, 2.62) | 2.27 (1.63, 3.15) |
| p-trend < 0.01 | p-trend < 0.01 | p-trend < 0.01 | |||
Abbreviations—aOR: adjusted odds ratio; CI: confidence interval; cOR: crude odds ratio; REF: reference; CRP: C-reactive protein; SII: systemic immune-inflammation index. † The model adjusted for age; sex; race; education; marital status; smoking; relative fat mass; physical activity; alcohol use; dietary intake of carbohydrates, total fat, protein, and energy; and multimorbidity. § The model adjusted for the same set of covariates, but corrected for the NHANES sampling weight.