Table 3.
Subgroup analysis for association between inflammatory biomarkers and sarcopenia, NHANES 1999–2006 (n = 2483).
| Variables | CRP (mg/L) | p-Trend | SII (×109 cells/L) | p-Trend | ||||
|---|---|---|---|---|---|---|---|---|
| aOR and 95% CI | aOR and 95% CI | |||||||
| 1.2–2.5 vs. < 1.2 | 2.6–5.2 vs. <1.2 | ≥5.3 vs. <1.2 | 365.7–503.6 vs. <365.7 |
503.7–704.0 vs. < 365.7 |
≥704.1 vs. <365.7 |
|||
| Age (year) | ||||||||
| <70 (n = 1319) | 0.91 (0.57, 1.47) | 1.07 (0.66, 1.76) | 1.7 (0.70, 1.94) | 0.48 | 0.79 (0.48, 1.32) | 1.72 (1.04, 2.85) | 1.65 (1.00, 2.72) | <0.01 |
| ≥70 (n = 1164) | 1.21 (0.81, 1.82) | 1.57 (1.03, 2.39) | 1.46 (0.94, 2.27) | 0.04 | 0.98 (0.62, 1.55) | 1.41 (0.91, 2.17) | 2.24 (1.45, 3.46) | <0.01 |
| p-interaction = 0.74 | p-interaction = 0.28 | |||||||
| Sex | ||||||||
| Female (n = 1292) | 0.91 (0.57, 1.45) | 1.21 (0.76, 1.95) | 1.00 (0.62, 1.62) | 0.71 | 0.74 (0.44, 1.22) | 1.45 (0.91, 2.30) | 1.66 (1.04, 267) | <0.01 |
| Male (n = 1191) | 1.22 (0.73, 1.69) | 1.29 (0.82, 2.00) | 1.40 (0.86, 2.26) | 0.13 | 1.10 (0.69, 1.76) | 1.35 (0.84, 2.16) | 2.14 (1.36, 3.37) | <0.01 |
| p-interaction = 0.63 | p-interaction = 0.63 | |||||||
| Multimorbidity | ||||||||
| No (n = 894) | 1.04 (0.61, 1.75) | 1.48 (0.86, 2.53) | 0.97 (0.54, 1.74) | 0.66 | 1.40 (0.81, 2.39) | 1.84 (1.04, 3.27) | 2.72 (1.53, 4.84) | <0.01 |
| Yes (n = 1589) | 1.00 (0.68, 1.48) | 1.24 (0.89, 1.87) | 1.56 (1.03, 2.36) | 0.02 | 0.64 (0.40, 1.01) | 1.29 (0.85, 1.94) | 1.66 (1.11, 2.46) | <0.01 |
| p-interaction = 0.32 | p-interaction = 0.28 |
Abbreviations—aOR: adjusted odds ratio; CI: confidence interval; CRP: C-reactive protein; SII: systemic immune-inflammation index. The model was adjusted for the same set of covariates as the primary model, except for those used for stratification.