Table 5.
Loaded APR | 21 mg | 25 mg | 30 mg | ||||
---|---|---|---|---|---|---|---|
% Ratio (O:S:Cs) | Time | Z-Average (nm) | PDI | Z-Average (nm) | PDI | Z-Average (nm) | PDI |
30:10:60 | 0 h | 48.06 ± 5.10 | 0.045 | 49.77 ± 3.73 | 0.022 | 52.24 ± 5.56 | 0.045 |
1 h | 48.20 ± 5.53 | 0.053 | 49.52 ± 6.78 | 0.075 | 52.97 ± 8.69 | 0.108 | |
2 h | 47.52 ± 25.04 | 0.035 | 53.99 ± 24.73 | 0.266 | 96.28 ± 24.67 | 0.288 | |
4 h | 48.97 ± 8.53 | 0.121 | 124.8 ± 28.22 | 0.204 | 130.8 ± 33.3 | 0.260 | |
20:10:70 | 0 h | 36.69 ± 2.19 | 0.014 | 38.21 ± 4.16 | 0.047 | 38.96 ± 4.24 | 0.047 |
1 h | 38.40 ± 5.34 | 0.077 | 38.97 ± 5.32 | 0.074 | 39.84 ± 7.25 | 0.133 | |
2 h | 36.87 ± 4.91 | 0.071 | 44.60 ± 9.35 | 0.176 | 63.63 ± 12.88 | 0.164 | |
4 h | 161.2 ± 45.02 | 0.312 | 546.5 ± 214.2 | 0.614 | 674.1 ± 322.0 | 0.913 | |
30:20:50 | 0 h | 28.08 ± 2.08 | 0.022 | 29.19 ± 3.79 | 0.068 | 28.96 ± 3.23 | 0.050 |
1 h | 28.18 ± 1.63 | 0.013 | 28.17 ± 2.14 | 0.023 | 28.77 ± 2.28 | 0.025 | |
2 h | 28.03 ± 3.22 | 0.053 | 27.95 ± 3.43 | 0.060 | 30.77 ± 8.01 | 0.271 | |
4 h | 29.14 ± 6.75 | 0.215 | 118.4 ± 26.10 | 0.194 | 3059 ± 1530 | 1 | |
10:30:60 | 0 h | 23.16 ± 5.96 | 0.265 | 20.07 ± 5.48 | 0.298 | 496.7 ± 248.4 | 1 |
1 h | 16.55 ± 2.73 | 0.109 | 2686 ± 1343 | 1 | 649.6 ± 275.6 | 0.720 | |
2 h | 205.3 ± 57.75 | 0.317 | 1054 ± 508 | 0.927 | 4637 ± 2319 | 1 | |
4 h | 1897 ± 949 | 1 | 2568 ± 1284 | 1 | 4673 ± 2337 | 1 | |
10:40:50 | 0 h | 14.40 ± 2.23 | 0.096 | 15.36 ± 3.02 | 0.154 | 14.27 ± 1.43 | 0.040 |
1 h | 14.54 ± 1.98 | 0.083 | 16.29 ± 3.76 | 0.213 | 75.08 ± 14.99 | 0.160 | |
2 h | 14.60 ± 1.86 | 0.062 | 26.51 ± 5.57 | 0.177 | 728.9 ± 327.3 | 0.806 | |
4 h | 14.66 ± 1.70 | 0.048 | 194.8 ± 59.85 | 0.377 | 1118 ± 559 | 0.969 | |
20:40:40 | 0 h | 21.25 ± 5.84 | 0.302 | 24.33 ± 7.49 | 0.379 | not dissolved | |
1 h | 20.36 ± 5.24 | 0.265 | 22.76 ± 6.75 | 0.352 | |||
2 h | 22.13 ± 6.29 | 0.323 | 22.68 ± 6.99 | 0.380 | |||
4 h | 103.0 ± 19.14 | 0.138 | 1828 ± 898 | 0.964 | |||
10:50:40 | 0 h | 13.99 ± 2.38 | 0.116 | 13.54 ± 1.22 | 0.033 | not dissolved | |
1 h | 14.01 ± 3.66 | 0.123 | 14.56 ± 2.65 | 0.133 | |||
2 h | 15.03 ± 1.07 | 0.141 | 445 ± 178.4 | 0.643 | |||
4 h | 15.26 ± 3.00 | 0.154 | 856.6 ± 400.9 | 0.876 | |||
20:50:30 | 0 h | 15.46 ± 2.26 | 0.086 | not dissolved | not dissolved | ||
1 h | 15.52 ± 2.05 | 0.071 | |||||
2 h | 15.60 ± 1.90 | 0.062 | |||||
4 h | 15.58 ± 1.86 | 0.057 | |||||
10:60:30 | 0 h | 13.67 ± 1.82 | 0.071 | not dissolved | not dissolved | ||
1 h | 13.71 ± 1.61 | 0.055 | |||||
2 h | 13.74 ± 1.47 | 0.046 | |||||
4 h | 13.80 ± 1.59 | 0.053 | |||||
20:60:20 | 0 h | 14.48 ± 1.80 | 0.061 | not dissolved | not dissolved | ||
1 h | 14.78 ± 1.84 | 0.065 | |||||
2 h | 14.85 ± 1.89 | 0.068 | |||||
4 h | 15.14 ± 2.03 | 0.072 |
Each value represented as mean ± SD (n = 3).