Table 1.

ADME properties of the oxime derivatives 13–18.

Compound	logP a	Solubility b [mg/mL]	Permeability c [10−6 cm/s]	PPB d	CNS e
13	3.95	0.004	23.6	83%	−1.86
14	3.70	0.009	23.7	77%	−1.77
15	4.27	0.002	23.3	90%	−2.05
16	3.32	0.009	23.4	77%	−1.82
17	3.58	0.01	23.6	81%	−1.92
18	3.94	0.01	23.6	83%	−1.86

^a lipophilicity logP (<−2.0 very hydrophilic, −2.0–(−1.0) hydrophilic, −1.0–4.2 optimal, 4.2–5.0 lipophilic); ^b solubility (<0.01 highly insoluble, 0.01–0.10 insoluble, >0.10 soluble); ^c Caco permeability (<1.0 × 10⁻⁶ poorly permeable, 1.0–7.0 × 10⁻⁶ moderately permeable, >7.0 × 10⁻⁶ highly permeable); ^d PPB—plasma-protein binding (10–40% weakly bound, 40–80% moderately, 80–90% strongly bound, >90% extensively bound); ^e CNS < −3.5 non-penetrant, −3.50–(−3.0) weak penetrant, >−3.0 penetrant); (ACD/Percepta (ver. 14.2.0; Build 2977; ACD/Laboratories, Toronto, ON, Canada).