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. 2021 Nov 19;10(11):3236. doi: 10.3390/cells10113236

Figure 3.

Figure 3

Effect of doxycycline (doxy) on ECM disarray and myofibroblast differentiation in hEDS cells. IF analyses of FN-, COLLI-, and TNs-ECM organization, αvβ3 integrin and Snail1/Slug transcription factor expression, and α-SMA cytoskeleton assembly in hEDS fibroblasts untreated and treated with 50 and 100 µM of doxy in complete MEM for 2 (FN and αvβ3 integrin), 4 (COLLI and TNs), 6 (α-SMA), and 8 (Snail1/Slug) days. The images are representative of 6 different patients’ cell strains. Scale bar: 12 μm.