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. 2021 Nov 12;22(22):12253. doi: 10.3390/ijms222212253

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The main steps of primary ciliary vesicle docking to DAPs during ciliogenesis. (1) After the conversion of the mother centriole into the basal body, the CP110–CEP97 protein complex caps the basal body and hinders ciliogenesis initiation. (2) Docking of small ciliary vesicles to DAPs leads to the formation of distal appendage vesicles (DAVs). (3) Larger primary ciliary vesicles (PCVs) form from smaller DAVs (facilitated by EDH1 and SNAP29 proteins). (4) Recruitment of TTBK2 and removal of the inhibitory CP110–CEP97 complex. (5) Rab8-positive vesicle docks at the centrosome, membranes are extended, and the axoneme is elongated, leading to (6) the completion of cilium formation. Image was created by BioRender.