Table 1.
The number of compounds in DS that could bind to thrombosis-related enzymes.
| Number | Target Name | PDB ID | Number of Compounds |
|---|---|---|---|
| 1 | Antithrombin III (ATIII) | 1R1L | 160 |
| 2 | Coagulation factor IIa (F2) | 5AFY | 143 |
| 3 | von Willebrand factor (VWF) | 4C2A | 143 |
| 4 | Coagulation factor XI (F11) | 6TS4 | 110 |
| 5 | Plasminogen activator inhibitor (PAI) | 1JRR | 100 |
| 6 | Neuronal acetylcholine receptor beta-2 (CHRNB2) | 6NCJ | 88 |
| 7 | DNA topoisomerase II (TOP2) | 3QX3 | 73 |
| 8 | Neuronal acetylcholine receptor alpha-2/alpha-3 (CHRNA2/A3) | 4ZK4 | 50 |
| 9 | Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) | 3T3M | 43 |
| 10 | Coagulation factor Xa (F10) | 2JKH | 40 |
| 11 | P-selectin (SELP) | 1G1S | 38 |
| 12 | Neuronal acetylcholine receptor alpha-2/alpha-3 (CHRNA2/A3) | 5FJV | 36 |
| 13 | Neuronal acetylcholine receptor alpha-7 (CHRNA7) | 5AFN | 36 |
| 14 | Tyrosine-protein kinase SYK (SYK) | 4YJR | 19 |
| 15 | DNA topoisomerase II (TOP2) | 1ZXN | 16 |
| 16 | P2Y purinoceptor 1 (P2RY1) | 4XNV | 5 |
| 17 | Plasminogen activator inhibitor (PAI) | 2HI9 | 4 |
| 18 | Coagulation factor IX (F9) | 5JB9 | 4 |
| 19 | Carboxypeptidase B2 (CPB2) | 4P10 | 3 |
| 20 | Platelet glycoprotein Ib alpha (CD42b) | 4CH2 | 3 |
| 21 | Arachidonate 5-lipoxygenase (5-LOX) | 3V99 | 2 |
| 22 | Plasminogen activator inhibitor (PAI) | 4G8R | 2 |
| 23 | Proteinase activated receptor 1 (F2R) | 3VW7 | 1 |
| 24 | P2Y purinoceptor 12 (P2RY12) | 4PXZ | 0 |
| 25 | HMG-CoA reductase (HMGCR) | 2R4F | 0 |