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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Nat Med. 2021 Oct 18;27(11):1921–1927. doi: 10.1038/s41591-021-01521-4

Extended Data Fig. 7. Multiple CH events bring higher risk of developing malignancies.

Extended Data Fig. 7

a-b) Multiple CH amplify risk of myeloid and lymphoid malignancies irrespective of the type of alterations. The analysis was performed among individuals with both WES and SNP-array data. Dashed curves indicate groups with multiple CH events. c-d) Multiple mCAs amplify risk of myeloid and lymphoid malignancies. (a-d) Since A-mCA were associated with risk of both myeloid and lymphoid malignancies, these are combined with M-mCA in the analysis of myeloid malignancies and with L-mCA in the analysis of lymphoid malignancies. Data are presented as hazard ratio and 95% confidence intervals, computed by using Cox proportional hazards model adjusting for age, sex, smoking, genetic ethnic ancestry, and genetic principal components 1–5. Individuals with >1 M-mCA/A-mCA and >1 L-CHIP were excluded in the multivariable Cox proportional hazard model due to small sample size and <3 events. HR, hazard ratio; CI, confidence interval.