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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Nat Med. 2021 Oct 18;27(11):1921–1927. doi: 10.1038/s41591-021-01521-4

Extended Data Fig. 9. Abnormal CBC parameters increase risk of myeloid and lymphoid malignancies.

Extended Data Fig. 9

Both high and low myeloid cell parameters (neutrophil count, platelet count, or red blood cell count) are associated with increased risk of myeloid malignancies and high lymphocyte count is associated with increased risk of CLL/SLL in a) the WES cohort and b) the SNP-array cohort. (a-b) Data are presented as hazard ratio and 95% confidence intervals, computed by using Cox proportional hazards model adjusting for age, sex, smoking, genetic ethnic ancestry, and genetic principal components 1–5. Groups with small sample size and <3 events were excluded in the multivariable Cox proportional hazard model. CBC, complete blood count; High myeloid; high myeloid cell parameters, Low myeloid, low myeloid cell parameters; CLL, chronic lymphocytic leukemia, SLL, small lymphocytic lymphoma; HR, hazard ratio; CI, confidence interval.