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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Nat Med. 2021 Oct 18;27(11):1921–1927. doi: 10.1038/s41591-021-01521-4

Extended Data Fig. 10. Risk of mortality and coronary artery disease among CH cases.

Extended Data Fig. 10

a) M-CHIP and all classes of mCAs were associated with increased risk of all-cause-mortality but L-CHIP did not increase the risk of mortality. b) Only M-CHIP, A-mCA and U-mCA were associated with mortality unrelated to hematologic malignancies. c) M-CHIP is associated with increased risk of coronary artery disease. No other CH categories were associated with risk of coronary artery disease. (a-c) Data are presented as hazard ratio and 95% confidence intervals, computed by using Cox proportional hazards model adjusting for age, sex, smoking, genetic ethnic ancestry, and genetic principal components 1–5. HR, hazard ratio; CI, confidence interval; VAF, variant allele fraction; CF, cell fraction.