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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Nat Med. 2021 Oct 18;27(11):1921–1927. doi: 10.1038/s41591-021-01521-4

Extended Data Fig. 6. Co-occurrence of CHIP and mCA amplify risk of malignancies.

Extended Data Fig. 6

a) Risk of myeloid malignancies due to M-CHIP and M-mCA/A-mCA. b) Risk of lymphoid malignancies due to L-CHIP and L-mCA/A-mCA. (a-b) Since A-mCA were associated with risk of both myeloid and lymphoid malignancies, these are combined with M-mCA in the analysis of myeloid malignancies and with L-mCA in the analysis of lymphoid malignancies. Data are presented as hazard ratio and 95% confidence intervals, computed by using Cox proportional hazards model adjusting for age, sex, smoking, genetic ethnic ancestry, and genetic principal components 1–5. HR, hazard ratio; CI, confidence interval.