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Molecular mechanisms of plasticity in subcortical visual areas. Top, in WT animals before eye opening, thalamocortical neurons are fed by multiple and weak retinal inputs, while in WT adult animals retinal inputs are strong and reduced (refinement). Note that LTP and LTD can be induced at an immature stage. Bottom, in KO animals for proteins involved in synaptic pruning (C1p, NPS, MHC, LRRTM1, and others), no synaptic refinement occurs. Note that LTD is prevented in MHC KO.
