Table 5.
Association between PTEN/PI3K/mTOR coexpression and clinicopathological parameters of TNBC.
| Parameters | PTEN -/PI3K+/mTOR+ | PTEN +/PI3K-/mTOR- | p Value |
|---|---|---|---|
| np (%) | np (%) | ||
| Age at diagnosis | |||
| <50 | 4 (31) | 4 (28) | 0.99 |
| ≥50 | 9 (69) | 10 (72) | |
| Tumor type | |||
| Ductal | 5 (38) | 8 (56) | 0.28 |
| Lobular | 4 (31) | 1 (8) | |
| Other * | 4 (31) | 5 (36) | |
| Invasion | |||
| Absent | 9 (69) | 12 (84) | 0.38 |
| Present | 4 (31) | 2 (16) | |
| pp stage | |||
| I | 0 (0) | 5 (36) | 0.01 |
| II | 7 (54) | 8 (57) | |
| III and IV | 6 (46) | 1 (7) | |
| pT stage | |||
| T1 | 2 (15) | 5 (36) | 0.19 |
| T2 | 9 (70) | 9 (64) | |
| T3 and T4 | 2 (15) | 0 (0) | |
| pN stage | |||
| N0 | 4 (31) | 12 (84) | 0.01 |
| N1 | 5 (38) | 1 (8) | |
| N2 and N3 | 4 (31) | 1 (8) | |
| Histologic grade | |||
| I and II | 7 (54) | 10 (72) | 0.44 |
| III | 6 (46) | 4 (28) | |
| Metastases | |||
| M0 | 7 (54) | 13 (93) | 0.03 |
| M1 | 6 (46) | 1 (7) |
Abbreviations: np, number of patients per group; *—medullary, tubular, and other rare carcinoma types. Bold indicates statistically significant values, p ≤ 0.05.