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. 2021 Nov 19;22(22):12500. doi: 10.3390/ijms222212500

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Simvastatin protects RGCs from chronic OHT-induced cell death. (a) The retinas were either stained with H&E or processed by immunohistochemistry for Brn3a or cleaved caspase-3. Number of cells (b), number of Brn3a⁺ cells (c), and cleaved caspase-3⁺ cells (d) in the GCL were quantified. The number of RGCs was reduced and the number of cleaved caspase-3 was increased in the sutured retina. Simvastatin injection prevented RGC death and suppressed apoptosis. GCL: Ganglion cell layer, IPL: inner plexiform layer, INL: inner nuclear layer, OPL: outer plexiform layer, ONL: outer nuclear layer, RGCs: retinal ganglion cells, H&E: hematoxylin and eosin, OHT: ocular hypertension; * p < 0.05, ^† p < 0.01, ^‡ p < 0.001; n = 4 for each group.