Table 1.
Final Compounds synthetized and evaluated. The different bioisosteric cationic head are showed in blue, black and red respectively.
| Compounds | Linker (a-f) | Bioisosteric Cationic Head | 4-Subtituent | ||
|---|---|---|---|---|---|
| Fa-M2 | monocationic | biphenyl |
thieno[3,2-b]pyridin-1-ium
|
Pyrrolidinyl | |
| Fa-M1 | thieno[3,2-d]pyrimidin-1-ium
|
|
|||
| Fa-M3 |
thieno[2,3-d]pyrimidin-1-ium
|
||||
| Fg-9 | biscationic | biphenyl | thieno[3,2-b]pyridin-1-ium | Pyrrolidinyl |
|
| Fa-21 | thieno[3,2-d]pyrimidin-1-ium | ||||
| Fg-14 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-24 | thieno[3,2-d]pyrimidin-1-ium | Piperidinyl |
|
||
| Fg-30 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fg-10 | thieno[3,2-b]pyridin-1-ium | Azepanyl |
|
||
| Fa-22 | thieno[3,2-d]pyrimidin-1-ium | ||||
| Fg-18 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fp-1 | thieno[3,2-d]pyrimidin-1-ium | N-methyl-aniline |
|
||
| Fp-8 | thieno[2,3-d]pyrimidin-1-ium | p-Chloro-N-methyl aniline |
|
||
| Fg-12 | bipyridinyl | thieno[3,2-b]pyridin-1-ium | Pyrrolidinyl |
|
|
| Fg-17 | thieno[3,2-d]pyrimidin-1-ium | ||||
| Fg-13 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-27 | thieno[3,2-d]pyrimidin-1-ium | Piperidinyl |
|
||
| Fg-32 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-26 | thieno[3,2-d]pyrimidin-1-ium | Azepanyl |
|
||
| Fg-20 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fg-11 | bibenzyl | thieno[3,2-b]pyridin-1-ium | Pyrrolidinyl |
|
|
| Fg-16 | thieno[3,2-d]pyrimidin-1-ium | ||||
| Fg-15 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-25 | thieno[3,2-d]pyrimidin-1-ium | Piperidinyl |
|
||
| Fg-31 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-23 | thieno[3,2-d]pyrimidin-1-ium | Azepanyl |
|
||
| Fg-19 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Ff-1 | biphenethyl | thieno[3,2-b]pyridin-1-ium | Pyrrolidinyl |
|
|
| Ff-7 | thieno[3,2-d]pyrimidin-1-ium | ||||
| Ff-3 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-33 | thieno[3,2-d]pyrimidin-1-ium | Piperidinyl |
|
||
| Ff-6 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-29 | thieno[3,2-d]pyrimidin-1-ium | Azepanyl |
|
||
| Ff-35 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Ff-2 | diphenoxiethane | thieno[3,2-b]pyridin-1-ium | Pyrrolidinyl |
|
|
| Ff-8 | thieno[3,2-d]pyrimidin-1-ium | ||||
| Ff-4 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Fa-28 | thieno[3,2-d]pyrimidin-1-ium | Piperidinyl |
|
||
| Ff-5 | thieno[2,3-d]pyrimidin-1-ium | ||||
| Ff-34 | thieno[3,2-d]pyrimidin-1-ium | Azepanyl |
|
||
| Ff-36 | thieno[2,3-d]pyrimidin-1-ium | ||||