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. 2021 Oct 20;9(11):1215. doi: 10.3390/vaccines9111215

Figure 8.

Figure 8

LSDV neutralization responses elicited by LSDV(∆SOD)BEFV-Gb-M (circles) and LSDV(SODis)BEFV-Gb-M (diamonds) in cattle. Two groups of cattle (n = 10) were inoculated with 105 TCID50 per animal, subcutaneously, and boosted with 5 × 104 TCID50 32 days later. The animals were challenged with 107 TCID50 virulent LSDV 169 days post boost. Scatter plots show LSDV neutralization responses to LSDV(∆SOD)BEFV-Gb-M (a) and LSDV(SODis)BEFV-Gb-M (b) over time; (c–e) show comparative LSDV responses to LSDV(∆SOD)BEFV-Gb-M (circles) and LSDV(SODis)BEFV-Gb-M (diamonds) at 14, 30 and 169 dpb, respectively; (f,g) show LSDV responses to the naive control animals (triangles), LSDV(∆SOD)BEFV-Gb-M (circles) and LSDV(SODis)BEFV-Gb-M (diamonds) groups, 14 and 28 dpc, respectively. Different colour shades indicate responses after one (lime) or two (orange) vaccinations or LSDV challenge (red). dpb = days post boost, dpc = days post challenge. Statistical analyses were conducted using the Kruskal–Wallis test with Dunn’s multiple comparison test (a,b,f,g) and Mann–Whitney U test (c,d,e). Horizontal lines indicate median values. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.