Table 4.
Clinical trials based on various cellulosic polymers used in ocular drug delivery.
| Clinical Trial | Drug Used | Phase | Location of Work | NCT Number | Ref |
|---|---|---|---|---|---|
| HPMC 0.3% and sodium hyaluronate 0.18% for ocular surface disease in glaucoma | HPMC and sodium hyaluronate | Not applicable | Bangkok, Thailand | NCT01284439 | [158] |
| Assess the safety and efficacy of CsA ophthalmic gel in subjects with moderate to severe dry eye disease | CsA ophthalmic gel, Hypromellose eye drop and placebo |
3 | China | NCT04541888 | [159] |
| Effect of topical besifloxacin on ocular surface bacterial microbiota prior to cataract surgery | Besifloxacin, HPMC ophthalmic solution | 1 | Mexico | NCT04542759 | [160] |
| An efficacy and safety study of bimatoprost alone compared with travoprost and timolol in glaucoma or ocular hypertension | Hypromellose (0.3%), Bimatoprost (0.01%), travatan (0.004%), timolol (0.5%) | 4 | Barrie, Ontario, Canada. | NCT01881126 | [161] |
| Efficacy and safety study of bimatoprost alone compared with travoprost and timolol in glaucoma or ocular hypertension | Hypermellose (0.3%), Bimatoprost (0.01%), Travoprost (0.004%), Timolol (0.5%). | 4 | United state | NCT02097719 | [162] |
| Evaluate the safety and efficacy of a new artificial tear for use after LASIK surgery | CMC and glycerin-based artificial tear | Not applicable | United state | NCT00544713 | [163] |
| Safety and efficacy of Alphagan P and Lumigan in subjects previously treated with latanoprost for glaucoma and hypertension | Hypromellose (0.2%), Brimonidine tartrate (0.1%), bimatoprost (0.2%), latanoprost (0.005%). | 4 | United state | NCT01525173 | [164] |
| Efficacy study of ketorolac and HPMC to treat dry eye | Ketorolac and HPMC | 2 | United state | NCT03693183 | [165] |
| The effect of BAK on the blood-aqueous barrier of pseudophakic patients | HPMC and CMC | 4 | Brazil | NCT01280110 | [166] |
| Efficacy, Tolerability, and comfort of Hypromellose eyedrop in patients undergoing LASIK surgery | Pre LASIK Hypromellose (0.3%), post LASIK Hypromellose (0.3%). | 4 | India | NCT00909324 | [167] |
| Assessment of alcon’s ocular image quantification system | Olopatadine HCL, Patanol (0.1%), dextran 70 (0.1%), HPMC (0.3%) | 4 | United state | NCT01282138 | [168] |
| Corneal protection used during cataract surgery | HPEC (2% gel), BSS | Not applicable | China | NCT02363530 | [169] |
| Interval intraocular pressure in intravitreal injection study (IIII) | Hypromellose, travatan, timolol | Not applicable | Hong kong | NCT04868175 | [170] |