Table 10.

Application of HEC in ocular drug delivery.

Cellulosic Polymer	Drug Used	Application of Polymer	Effect on Drug Property	Ref
HEC	Dorzolamide	Sustained release, decrease dosing frequency	Reduction in IOP for 2 week an drug also showed neuroprotective effect	[68]
	Ketorolac tromethamine	Effective carrier for delivery of the drug	Enhanced EE% and drug loading was 45.4 and 36.3%	[224]
	Azithromycin	Sustained release and improve ocular performance	Enhanced EE% up to 62.167 ± 0.07% and prolonged drug release for 121 h	[225]
	Betaxolol	Prolongation of pre-corneal retention and enhanced relative bioavailability	Enhanced encapsulation efficiency (69 ± 5%) and relative bioavailability (280 and 254.7%)	[226]
	Phenylephrine and tropicamide	Extended-release	Enhanced force of bioadhesion (5688 mpa) and mucoadhesive property 172.75 ± 50.81 pa and enhanced bioavailability	[227]
	Povidone-iodine	Additive effect for feline herpesvirus type1 and C Felis.	Enhanced relative cell viability up to 52.7 ± 2.1% v/v and significantly reduced C. felis growth	[228]
	Cysteamine	Viscosity enhancer	Enhanced drug released for 45–50 min, and combined with bioadhesive nature of gel results in enhanced bioavailability	[229]
	Oxidized hydroxy ethyl cellulose	Safe development, fashionable, and PH detectable contact lenses	Non-cytotoxic with excellent photochromic property of 2 × 10−4 and transparency up to 93% with compression strength 8.5 MPa	[63]