Table 11.
Application of HPC, CA, and CAP in ocular drug delivery.
| Cellulosic Polymer | Drug Used | Formulation | Application of Polymer | Effect on Drug Property | Ref |
|---|---|---|---|---|---|
| HPC | Timolol maleate | Instantly soluble solid eye drops | Increases the ocular residence time of drug | Enhanced corneal residence time by interacting with cornea because of mucoadhesive property of HPC | [129] |
| CA | Betaxolol hydrochloride | Silicone hydrogel based contact lenses | Sustained release up to 66% in 72 h, prolonged residence time of the drug | Enhanced bioavailability up to 50%, initial high burst release of 24.5 ± 5.2 µg/mL (to achieved therapeutic concentration) than decreased in release up to 1.7 ± 1.0 µg/mL at 6 h (sustained release) | [130] |
| CAP | Ibuprofen | Nanoparticle particle dispersed gel | Prolonged residence time and control permeation of drug | In vitro drug release was 70% at 8 h | [105] |