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. 2021 Nov 22;14(11):1201. doi: 10.3390/ph14111201

Table 11.

Application of HPC, CA, and CAP in ocular drug delivery.

Cellulosic Polymer Drug Used Formulation Application of Polymer Effect on Drug Property Ref
HPC Timolol maleate Instantly soluble solid eye drops Increases the ocular residence time of drug Enhanced corneal residence time by interacting with cornea because of mucoadhesive property of HPC [129]
CA Betaxolol hydrochloride Silicone hydrogel based contact lenses Sustained release up to 66% in 72 h, prolonged residence time of the drug Enhanced bioavailability up to 50%, initial high burst release of 24.5 ± 5.2 µg/mL (to achieved therapeutic concentration) than decreased in release up to 1.7 ± 1.0 µg/mL at 6 h (sustained release) [130]
CAP Ibuprofen Nanoparticle particle dispersed gel Prolonged residence time and control permeation of drug In vitro drug release was 70% at 8 h [105]