. 2021 Oct 25;14(11):1077. doi: 10.3390/ph14111077

Table 3.

The frequencies of Class I HLA-associated drug hypersensitivity and related drug adverse reactions.

HLA Pharmacogenetics Marker	Allele Frequency (%)						Drug	ADR Type
HLA Pharmacogenetics Marker	Thai Population (n = 470) [25]	African Americans (n = 252) [26]	North American (n = 187) [26]	Caucasians (n = 265) [26]	Hispanics (n = 234) [26]	Asians (n = 358) [26]	Drug	ADR Type
HLA-A*01:01	2.23	5.56	7.49	15.09	5.98	1.53	Phenobarbital	SCARs, MPE [32]
HLA-A*24:02	11.49	2.78	22.73	6.6	12.18	18.94	Carbamazepine	SJS/TEN [33]
							Phenytoin	SJS/TEN [33]
							Lamotrigine	SJS/TEN, MPE [33]
HLA-A*30:02	0	4.96	1.87	0.57	3.42	0.14	Amoxicillin-Clavulanate	DILI [34]
HLA-A*31:01	0.85	0.79	7.75	3.21	4.91	3.06	Carbamazepine	CADRs, SJS/TEN, DRESS, MPE [35,69,70]
	0.85	0.79	7.75	3.21	4.91	3.06	Lamotrigine	SCARs [36]
HLA-A*33:03	11.17	3.97	0.53	0.57	1.07	11.7	Allopurinol	SJS/TEN [71,72]
							Ticlopidine	DILI [73]
HLA-A*68:01	0.96	2.58	5.62	3.02	2.56	0.28	Lamotrigine	SCARs [37]
HLA-B*13:01	5.96	0	0	0	0	3.34	Phenytoin	SCARs [38]
							Phenobarbital	DRESS [32]
							Dapsone	DRESS [39]
							Salazosulfa-pyridine	DRESS [40]
HLA-B*15:02	7.66	0.2	0	0	0	4.87	Carbamazepine	SJS/TEN [35,69,70]
							Oxcarbazepine	MPE, SJS [35]
							Phenytoin	SJS/TEN [35]
							Cotrimoxazole	SJS/TEN [74]
HLA-B*15:11	0.21	0	0	0	0	0.28	Carbamazepine	SJS/TEN [35,69]
HLA-B*15:13	0.96	0	0	0	0	0.28	Phenytoin	SJS/TEN, DRESS [33,75,76]
HLA-B*35:05	1.91	0	0	0.38	0.85	0.14	Nevirapine	SJS/TEN, DRESS [69,77]
HLA-B*38:01	0	0.4	1.07	2.45	1.71	0.42	Co-trimoxazole	SJS/TEN [78]
HLA-B*38:02	4.26	0	0	0.19	0	6.55	Oxcarbazepine	MPE [79]
							Co-trimoxazole	SJS/TEN [78]
HLA-B*51:01	4.26	1.2	11.23	5.66	6.2	6.69	Phenobarbital	SJS/TEN [32]
HLA-B*56:02	0.11	0	0	0	0	0.28	Phenytoin	DRESS [38]
HLA-B*57:01	1.17	2.39	2.14	4.15	1.92	0.97	Abacavir	AHS [35,69,80]
							Flucloxacillin	DILI [81]
HLA-B*58:01	6.38	6.37	0.8	1.13	1.07	7.38	Allopurinol	CADRs, SCARs, MPE, SJS/TEN, DRESS [35,69,71,82]
HLA-B*59:01	0	0	0	0	0	0.56	Methazolamide	SJS/TEN [83]
HLA-C*03:02	7.77	2.78	0.27	0.38	1.07	7.66	Allopurinol	SJS/TEN [71,72]
HLA-C*06:02	4.26	11.31	5.62	8.68	6.84	3.62	Co-trimoxazole	SJS/TEN [74]
HLA-C*08:01	10.32	0.2	2.41	0	1.71	11.28	Carbamazepine	SJS/TEN [33]
							Phenytoin	SJS/TEN [84]
							Allopurinol	SJS/TEN [84]
							Co-trimoxazole	SJS/TEN [74]