Table 2.
Summarized information about claudin proteins expression in GI cancer cell line. ↑—up-regulated, ↓—downregulated.
| Cancer | Claudin | Expression | Described Effects on Cells | References |
|---|---|---|---|---|
| Oral | 1 | ↑ | Invasiveness ↑ Proliferation ↑ |
[54,55,56,57,58,59] |
| 7 | ↓ | Invasiveness ↑ | [60,61] | |
| Oesophageal | 1 | ↑ | Proliferation ↑ Metastasis ↑ Invasiveness ↑ |
[62] |
| 4 | ↓ | Growth ↑ Colony formation ↑ Invasiveness ↑ |
[63] | |
| 7 | ↓ | Invasiveness ↑ Metastasis ↑ Tumour progression ↑ |
[64] | |
| Liver | 1 | ↓ | Invasiveness ↑ Metastasis ↑ |
[65] |
| 3 | ↓ | Invasiveness ↑ Metastasis ↑ Colony formation ↑ |
[66] | |
| 10 | ↑ | Angiogenesis ↑ Invasiveness ↑ |
[67] | |
| Gastric | 1 | ↑ | Apoptosis ↑ Invasiveness ↑ Migration ↑ Colony formation ↑ |
[68,69,70] |
| 4 | ↑ | Invasiveness ↑ Migration ↑ |
[71,72] | |
| 4 | ↓ | Migration ↑ Proliferation ↑ Invasiveness ↑ |
[73] | |
| 6 | ↑ | Migration ↑ Proliferation ↑ Invasiveness ↑ Colony formation ↑ |
[74,75] | |
| 7 | ↑ | Migration ↑ Proliferation ↑ Invasiveness ↑ Colony formation ↑ EMT ↑ |
[75,76] | |
| 9 | ↑ | Migration ↑ Proliferation ↑ Invasiveness ↑ |
[75] | |
| 11 | ↓ | Migration ↑ Invasiveness ↑ |
[77] | |
| Colorectal | 1 | ↑ | Growth ↑ Colony formation ↑ Migration ↑ Invasiveness ↑ |
[78,79] |
| 2 | ↑ | Colony formation ↑ Proliferation ↑ |
[80] | |
| 3 | ↓ | Proliferation ↑ Invasiveness ↑ EMT ↑ |
[81] | |
| 7 | ↓ | EMT ↑ Colony formation ↑ Growth ↑ Invasiveness ↑ |
[82,83] |