Table 4.
Indicators of oxidative stress and antioxidant capacities of liver tissue in patients with recurrent and non-recurrent hepatocellular carcinoma 1.
| Characteristics | Recurrence (n = 48) | Non-Recurrence (n = 44) | ||
|---|---|---|---|---|
| Adjacent Normal Tissue | HCC Tissue | Adjacent Normal Tissue | HCC Tissue | |
| Oxidative stress marker | ||||
| MDA (μmol/g protein) |
0.7 ± 0.1 (0.7) |
0.5 ± 0.1 (0.3) |
0.6 ± 0.1 (0.4) |
0.7 ± 0.1 (0.5) |
| GSSG/GSH ratio | 14.5 ± 1.8 2 (14.1) |
16.4 ± 3.4 2 (13.8) |
21.9 ± 2.8 3,# (19.8) |
23.9 ± 3.6 3 (18.2) |
| Antioxidant capacities | ||||
| GSH (μmol/g protein) |
20.4 ± 2.4 (21.4) |
30.6 ± 3.9 * (26.5) |
14.5 ± 3.2 # (3.3) |
20.0 ± 3.9 *,# (6.6) |
| GSSG (μmol/g protein) |
33.5 ± 1.5 2 (32.5) |
47.0 ± 4.4 2,* (43.1) |
38.7 ± 2.1 3 (35.7) |
54.0 ± 4.7 3,* (48.4) |
| TEAC (μmol/g protein) |
214.1 ± 9.7 (209.6) |
268.3 ± 16.5 * (262.7) |
202.6 ± 11.6 (189.3) |
247.8 ± 17.0 * (218.7) |
1 Values are means ± standard error with median in parentheses. MDA, malondialdehyde; GSH, glutathione; GSSG, glutathione disulfide; TEAC, trolox equivalent antioxidant capacity. 2 n = 13. 3 n = 23. * Values are significantly different from adjacent normal tissue (p < 0.05). # Values are significantly different from recurrence group (p < 0.05).