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. 2021 Oct 30;9(11):1472. doi: 10.3390/healthcare9111472

Table 1.

Mean GHQ-12, AQ, and WHOLQOL-BREF scores with individuals exceeding the cut-off.

Assessment Tool Total EDS Subtype F (df, p-Value) Fisher’s (p-Value)
sEDS cEDS hEDS vEDS
17 (10.9%) 89 (57.1%) 47 (30.1%) 3 (1.9%)
GHQ-12 Likert (SD) 19.46 (4.81) 23.18 (5.14) * 18.60 (4.31) 19.87 (5.08) 17.33 (2.52) 5.021
(3, p = 0.002)
n (%) with GHQ-2 score ≥ 14 142 (91.0%) 17 (100%) 78 (87.6%) 44 (93.6%) 3 (100%) n.s.
AQ (SD) 19.99 (6.80) 22.65 (6.86) 19.57 (6.29) 20.19 (7.62) 14.33 (3.51) 1.705
(3, p = 0.168)
n (%) with AQ score ≥ 32 11 (7.1%) 2 (11.8%) 5 (5.6%) 4 (8.5%) 0 n.s.
WHOQOL-General QoL(self-rated) (SD) 3.00 (0.95) 2.35 (0.79) * 3.16 (0.95) 2.98 (0.92) 2.33 (0.58) 4.182
(3, p = 0.007)
WHOQOL-Health satisfaction(self-rated) (SD) 2.46 (1.00) 2.12 (0.78) 2.57 (1.00) 2.38 (1.05) 2.00 (1.00) 1.359
(3, p = 0.258)
Physical Health (SD) 45.56 (22.41) 36.55 (22.75) 49.88 (22.11) 39.21 (20.06) * 67.86 (28.57) 4.557
(3, p = 0.004)
n (%) with domain score < 70 127 (81.4%) 15 (88.2%) 68 (76.4%) 42 (89.4%) 2 (66.7%) n.s.
n (%) with severe impairment 28 (17.9%) 6 (35.3%) 8 (9.0%) * 14 (29.8%) 0 12.943
(p = 0.003)
Psychological (SD) 55.05 (19.50) 38.97 (19.98) * 58.71 (17.70) 53.72 (20.01) 58.33 (20.83) 5.427
(3, p = 0.001)
n (%) with domain score < 70 115 (73.7%) 14 (82.4%) 62 (69.7%) 37 (78.7%) 2 (66.7%) n.s.
n (%) with severe impairment 30 (19.2%) 8 (47.1%) * 12 (13.5%) 10 (21.3%) 0 9.427
(p = 0.018)
Social Relationship (SD) 53.37 (24.24) 38.24 (21.66) * 57.12 (23.69) 50.71 (24.62) 69.44 (4.81) 3.734
(3, p = 0.013)
n (%) with domain score < 70 115 (73.7%) 16 (94.1%) 62 (69.7%) 35 (74.5%) 2 (66.7%) n.s.
n (%) with severe impairment 30 (19.2%) 7 (41.2%) 13 (14.6%) 10 (21.3%) 0 n.s.
Environment (SD) 54.43 (17.27) 47.24 (17.85) 56.74 (17.18) 52.73 (17.20) 53.13 (5.41) 1.694
(3, p = 0.171)
n (%) with domain score < 70 130 (83.3%) 15 (88.2%) 72 (80.9%) 40 (85.1%) 3 (100%) n.s.
n (%) with severe impairment 23 (14.7%) 5 (29.4%) 7 (7.9%) 11 (23.4%) 0 9.226
(p = 0.018)

Legend: AQ: Autism quotient; EDS: Ehler Danlos Syndrome (c: Classical; h: Hypermobile; s: Suspected; v: Vascular); GHQ: Global Health Questionnaire; QoL: Quality of Life; SD: Standard deviation; WHOQOL: World health Organization Quality of Life assessment tool. Bold values refer to significant F statistics or Fisher’s exact test. Italic with * refers to significant post-hoc comparisons corrected with Bonferroni’s method. Cronbach’s α >0.7 for each assessment tool.