Table 3.
Fractional inhibitory concentration indices (FICIs) of different BrCl-flav—fluconazole combinations against Candida spp strains.
| Candida sp. Strains | MIC (µg/mL) | FICI | Interaction | |||
|---|---|---|---|---|---|---|
| Alone | In Combination | |||||
| BrCl-Flav | Fluconazole | BrCl-Flav | Fluconazole | |||
| C. albicans | 15.62 | 1000 | 15.62 | 0.16 | 1 | IND |
| 7.81 | 7.81 | 0.50 | SYN | |||
| 3.9 | 7.81 | 0.25 | SYN | |||
| 1.95 | 7.81 | 0.12 | SYN | |||
| C. krusei | 15.62 | 62.5 | 15.62 | 0.12 | 1 | IND |
| 7.81 | 31.25 | 1 | IND | |||
| 3.9 | 31.25 | 0.75 | ADD | |||
| 1.95 | 31.25 | 0.62 | ADD | |||
| C. parapsilosis | 15.62 | 3.9 | 15.62 | 0.12 | 1.03 | IND |
| 7.81 | 1.95 | 1 | IND | |||
| 3.9 | 1.95 | 0.75 | ADD | |||
| 1.95 | 3.9 | 1.12 | IND | |||
| C. glabrata | 15.62 | 125 | 15.62 | 31.25 | 1.25 | IND |
| 7.81 | 31.25 | 0.75 | ADD | |||
| 3.9 | 62.5 | 0.75 | ADD | |||
| 1.95 | 125 | 1.12 | IND | |||
MIC: Minimum inhibitory concentration; SYN: synergy (FICI ≤ 0.5); ADD: additivity (0.5 < FICI ≤ 1); IND: indifference (1 < FICI ≤ 4); the values are mean for at least three replicates.