Table 4.

Distribution of mutations in the FGA, FGB, and FGG genes according to the associated phenotype.

	Number of Mutations
Disease/Phenotype	FGA	FGB	FGG
Afibrinogenemia	55	24	14
Dysfibrinogenemia	38	17	50
Renal amyloidosis	14	0	0
Hypofibrinogenemia	13	30	41
Fibrinogen variant	4	3	7
Susceptibility to venous thromboembolism	3	0	0
Decreased fibrinogen levels?	2	0	0
Decreased fibrinogen levels	0	0	1
Hypodysfibrinogenemia	2	3	9
Afibrinogenaemia?	1	2	0
Afibrinogenemia/hypofibrinogenemia	1	1	1
Afibrinogenemia with recurrent venous thromboembolism	1	0	0
Amyloidosis, Ostertag-type	1	0	0
Deep vein thrombosis?	1	0	0
Dysfibrinogenemia?	1	0	1
Hemorrhages	1	3	0
Association with increased post-stroke mortality	1	0	0
Menorrhagia	1	0	1
Thrombosis	1	0	0
Venous thromboembolism?	1	0	0
Association with cerebral infarction	0	1	0
Epistaxis	0	1	1
Hypofibrinogenaemia?	0	1	1
Association with increased clot stiffness	0	1	0
Increased plasma fibrinogen levels	0	1	0
Thrombotic tendency	0	1	0
Protection against venous thromboembolism	0	1	0
Increased risk for deep venous thrombosis	0	0	1
Hypofibrinogenaemia with hepatic storage	0	0	3
Total (public HGMD repository)	142	90	131

Data were retrieved from the HGMD (http://www.hgmd.cf.ac.uk/, accessed on 20 July 2021) and references therein. Phenotypes are all those reported in such database (the question mark the uncertainty of the associated diagnosis).