Table 2.

The applications of exosomes as drug carriers.

Cancer Types	Loading Drug	Outcome	References
Hepatocellular carcinoma	cisplatin	Cisplatin-loaded exosomes inhibited the progression of hepatocellular carcinoma	[13]
Pancreatic cancer	paclitaxel	The anti-proliferative activity of paclitaxel increased compared with the free drug in pancreatic cancer	[84]
Breast cancer	doxorubicin	The immunogenicity and toxicity of doxorubicin increased significantly in breast cancer	[85]
Brain tumor	curcumin	Curcumin-loaded exosomes exhibited strongly targeted ability in the brain, effectively inhibiting tumor growth in vivo	[86]
Melanoma	acridine orange	The acridine orange encapsulated by exosomes prolonged drug delivery efficiency in melanoma	[87]
Breast tumor	miRNA let-7a	MiRNA let-7a loaded by exosomes could inhibit breast tumor growth	[88]
Glioblastoma	anti-miR-9	The anti-MiR-9 loaded by exosomes could sensitize the glioblastoma multiforme cells to chemotherapy drugs	[89]
Sarcomas	TGFβ1 siRNA	The TGFβ1 siRNA loaded by exosomes could inhibit the growth of mouse sarcomas both in vitro and in vivo	[90]
Fibro sarcoma	98RAD51-siRNA, RAD52-siRNANA	The RAD52-siRNA loaded by exosomes could reduce the viability and proliferation of cancer cells	[91]
Pancreatic cancer	survivor -T34A	The survivor -T34A loaded by exosomes could induce apoptosis in various pancreatic adenocarcinoma cell lines and increase their sensitivity to gemcitabine	[92]