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m81 mAb can prevent fibrils formation in vitro and block aggregation process up to an oligomeric stage. To investigate m81 mAb fibril blockage potential in vitro, synthetic human IAPP (hIAPP) was incubated at 37 °C, together with Thioflavin T, to detect the increase in fibril size. m81 mAb was either added at time point = 0 or 100 min. hIAPP, human IAPP; Thio, Thioflavin T. Data are presented as mean ± SEM. ** p < 0.01, **** p < 0.0001.
