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. 2021 Nov 3;11(11):1141. doi: 10.3390/jpm11111141

Table 2.

Meta-analysis of Odds Ratios with 95% confidence interval for differences between the prevalence of Folate Receptor Alpha Autoantibodies in children with ASD to Various Comparison Groups. Odd ratios that are significant are bolded and italicized. Also listed are Cochran’s Q (Q), Heterogeneity Index (I2), Luis Furuya-Kanamori (LFK) Index and number of studies involved (N). Statistics are estimated by a random-effects model. Γ p < 0.05, ** p ≤ 0.001.

Comparison Group Odds Ratio (95% CI) Q I2 LFK N
Parents of ASD children

  • Blocking FRα autoantibody

 2.10 (1.05, 4.21) Γ 6.37 3

  • Binding FRα autoantibody

 3.62 (0.70, 18.84) 4.40 2

  • Either FRα autoantibody

 3.56 (1.62, 7.79) ** 8.60 Γ 65% −0.77 4
Typically Developing Siblings of ASD

  • Blocking FRα autoantibody

 2.00 (0.26, 15.21) 3.31 2

  • Binding FRα autoantibody

 1.32 (0.44, 3.99) 1.41 2

  • Either FRα autoantibody

 2.12 (0.40, 11.30) 3.12 2
Typically Developing Non-sibling

  • Blocking FRα autoantibody

 26.84 (7.84, 91.86) ** 1.02 2

  • Binding FRα autoantibody

 7.90 (0.70, 89.13) ** 2.81 2

  • Either FRα autoantibody

 19.03 (2.36, 153.58) ** 3.58 2
Developmentally Delayed without ASD

  • Blocking FRα autoantibody

 25.38 (3.29, 196.02) ** 1