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. 2021 Nov 4;11(11):2041. doi: 10.3390/diagnostics11112041

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Impact of GITR, GITRL, 4-1BB, or 4-1BBL expression on CLL patients’ survival. (A) Exemplary histogram plots for each surface marker of high and low expressing patients are shown by flow cytometry. (B–E) Overall survival of CLL patients according to GITR^lo and GITR^hi, GITRL^lo and GITRL^hi, 4-1BB^lo and 4-1BB^hi, and 4-1BBL^lo and 4-1BBL^hi expression (SFI) in Kaplan-Meier analysis. Low and high GITR/GITRL/4-1BB/4-1BBL expression levels are sub-grouped according to median of SFI levels of surface markers. Median OS for GITR^hi (continuous line) and GITR^lo cases (dotted line) was not reached (log-rank test). Median OS was reached in GITRL^hi (continuous line) and GITRL^lo (dotted line) was not reached (log-rank test). In 41BB^hi the median OS was 152 month (continuous line) and was not be reached in 4-1BB^lo (dotted line) and differed significantly (log-rank test). Median OS in 4-1BBL^hi and 4 1BBL^lo was not reached (dotted line; log-rank test).