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Activation of CTLA-4 in Treg cells leads to the inactivation of the immune response. αCTLA-4 can be used to mask the activity of Treg cells, thus enhancing the T cell binding ability and activation for tumor eradication. Reproduced from Aboulkheyr Es et al. [45] which is licensed under a Creative Commons Attribution-(CC BY 4.0) International License (http://creativecommons.org/licenses/by/4.0/).
