Figure 4.

Scheme representing the production of oxygen from H₂O₂ under laser irradiation, thus relieving hypoxia in the TME. (A) Formation of the nanocomplex, (B) intravenous injection of the nanoformulation and (C) mechanism of nanoformulation action inside the cell following combination therapy wherein Ce6 increases the efficiency of PDT and helps in imaging, Mn²⁺ increases ROS production, and oxygen is generated via reaction between intracellular H₂O₂ and hydrogen. Reproduced from Wu et al. [60] which is licensed under a Creative Commons Attribution-(CC BY 4.0) International License (http://creativecommons.org/licenses/by/4.0/).