Table 2.
CAV Grade | ISHLT CAV1 n = 5 | ISHLT CAV2 n = 4 | ISHLT CAV3 n = 20 | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Pre | CAV1 | Change | Pre | CAV2 | Change | Pre | CAV3 | Change | (CI) p value | |
Sm rad cm/s | 10.7 | 9.9 | −0.8 | 11.0 | 10.3 | 0.8 | 10.5 | 9.3 | 1.3 | (0.23–2.43) |
(±1.2) | (±0.7) | (±1.69) | (±2.2) | (±1.5) | (±2.2) | (±1.9) | (±2.9) | (±2.5) | 0.017 | |
Sm long cm/s | 11.0 | 9.2 | −1.8 | 10.8 | 10.8 | 0 | 10.6 | 9.5 | 1.4 | (0.21–2.66) |
(±1.4) | (±0.7) | (±1.3) | (±2.2) | (±2.2) | (±2.5) | (±2.2) | (±2.6) | (±2.8) | 0.021 | |
LV-EF % | 60.0 | 56.0 | −4.0 | 58.8 | 55.5 | −3.75 | 56.9 | 52.1 | 4.8 | (0.42–9.18) |
(±3.2) | (±11.6) | (±8.6) | (±4.1) | (±3.5) | (±1.1) | (±6.7) | (±12.0) | (±10.0) | 0.031 | |
ACR grade | ISHLT 1R n = 84 | ISHLT 2R n = 13 | ISHLT 3R n = 8 | |||||||
pre | 1R | change | (CI) p value |
pre | 2R | change | pre | 3R | change | |
Sm rad cm/s | 11.3 | 9.6 | −1.7 | (1.32–2.08) | 11.3 | 9.1 | −1.9 | 11.4 | 9.4 | −2.6 |
(±2.0) | (±2.0) | (±1.8) | <0.001 | (±1.7) | (±2.4) | (±2.3) | (±2.1) | (±2.1) | (±3.0) | |
Sm long cm/s | 11.8 | 10.0 | −2.0 | (1.66–2.34) | 11.7 | 9.1 | −2.3 | 11.9 | 9.1 | −3.4 |
(±1.7) | (±2.4) | (±1.6) | <0.001 | (±1.8) | (±2.9) | (±2.4) | (±1.8) | (±1.8) | (±1.9) | |
LV-EF % | 62.6 | 57.9 | −5.3 | (3.85–6.75) | 60.4 | 53.8 | −7.1 | 65.0 | 54.4 | −10.6 |
(±5.8) | (±8.8) | (±6.8) | <0.001 | (±4.0) | (±12.7) | (±16.2) | (±3.5) | (±14.5) | (±13.3) |
ACR, acute cellular rejection; CAV, cardiac allograft vasculopathy; CI, confidence interval; ISHLT, International Society for Heart and Lung Transplantation; long, longitudinal; LV-EF, left ventricular rejection fraction; rad radial; Sm, systolic wall motion peak velocity.