Table 4.

Correlation analysis between MMPs and immune infiltration levels. The correlations between individual MMPs and tumor purity, MMPs and infiltration levels of six TIICs (B-cells, CD4+ T-cells, CD8+ T-cells, macrophages, neutrophils, and dendritic cells) were analyzed by TIMER in COAD. r, the categorized Pearson’s correlation coefficient, was scored as follows: (---), r from −1.0 to −0.5, strong negative association; (--), −0.5 to −0.3, weak negative association; (-), −0.3 to 0.1, little association. (+), +0.1 to 0.3, little association; (++) +0.3 to +0.5, weak positive association; (+++), +0.5 to +1.0, strong positive association.

	Purity	B Cell	CD8+ T Cell	CD4+ T Cell	Macrophage	Neutrophil	Dendritic Cell
MMP1	-		+		+	+++	++
MMP2	--		+	++	+++	+++	+++
MMP3	-	-	+			++	+
MMP7	-	+				+
MMP8	-	-	+		++	++	++
MMP9	-		+	++	++	+++	+++
MMP10	-					+	+
MMP11	-		-	++	++		+
MMP12	-	+	++	+	++	+++	+++
MMP13	-		+	+	++	++	++
MMP14	--		+	+++	+++	+++	+++
MMP15			-	+	-
MMP16	-		+	++	+++	++	++
MMP17	-			++	+	+	+
MMP19	--	+	+	+++	++	++	++
MMP20
MMP21	-		+	+	+	+	+
MMP23A			-
MMP23B	-			++	+	+	+
MMP24			-	+		-	-
MMP25	--	+	+	++	+	+++	+++
MMP26				-		-	-
MMP27	-		+	+	+	+	+
MMP28	-		+	+	+	+	+