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. 2021 Nov 18;13(11):1956. doi: 10.3390/pharmaceutics13111956

Figure 3.

Figure 3

Cell viability of SIRC cells repeatedly exposed (6×) for 10 min with or without wash and with a step of 1.5 h between the repeated exposures (Short Time Repeated Exposure (S.T.R.E.)) to control formulations or delivery systems SLN B8, SLN B9, and SLN A8 diluted at 5 mg/mL. Dotted line is placed at 50% representing the cut-off value to determine cytotoxicity potential according to ECVAM protocol DB-ALM n° 17. Data represent the mean ± s.e.m. of three replicates for each condition. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001; **** p ≤ 0.0001. One sample t-test vs. cut-off 50%.