Figure 5.

Circ_0092367 Sponges MiR-1206 in PC Cells. (A) RIP assay was used to quantify the expression of circ_0092367 and miR-1206 in PC cells. (B) miR-1206 expression in PC cells was tested after either overexpression or knockdown of circ_0092367. (C,D) Decreased cell invasion (C) and gemcitabine resistance (D) in circ_0092367-overexpressed cells were rescued by miR-1206 mimic. (E, F) However, increased cell invasion (E) and gemcitabine resistance (F) in circ_0092367-knockdown cells were reversed by miR-1206 inhibitor. The experiments in (A–F) were repeated three times independently with similar results. *** p < 0.001.