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. 2021 Oct 28;9(11):2245. doi: 10.3390/microorganisms9112245

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Changes in the serotype distribution of pneumococci causing pneumococcal pneumonia by period. (A) Individual serotypes; (B) Frequency of episodes caused by serotypes included in pneumococcal vaccines. Asterisks indicate significant changes between 2011–2013 and 2017–19. Lines below the serotypes indicate the serotype composition of the different vaccines. PCV13: 13-valent pneumococcal conjugate vaccine (PCV); PCV15: 15-valent PCV; PCV20: 20-valent PCV; PPV23: 23-valent pneumococcal polysaccharide.