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. 2021 Nov 16;13(11):1942. doi: 10.3390/pharmaceutics13111942

Figure 2.

Figure 2

Manhattan Plot of the genome-wide association analysis in the discovery cohort for the case-control analysis. The association between the genotypes of 725,785 single nucleotide variants and risk of developing anthracycline-induced cardiotoxicity is shown. For the analysis, the cumulative epirubicin dose was used as covariate. All replicated SNVs are encapsulated in a red circle, as well as its name is displayed. The blue line represents the p-value threshold of 5 × 10−5.