Table 1.

Comparative antimicrobial activities of tested agents in vitro, against four most common species of yeast isolated from damaged voice prostheses.

Agent	MIC (µg/mL)			MFC (µg/mL)			MBIC (µg/mL)
	Range	50%	90%	Range	50%	90%	Range	50%	90%
	Candida albicans (n = 14)
Amphotericin B	0.5–512	0.5	1	0.5–512	0.5	1	0.5–512	1	32
Fluconazole	0.5–512	16	512	1–512	128	512	2–512	128	512
Omiganan	32–512	128	256	64–512	128	256	64–512	128	256
LL-37	16–512	512	512	64–512	512	512	64–512	512	512
CSA-13	0.5–8	2	8	1–8	4	8	2–16	4	8
CSA-131	0.5–2	0.5	2	0.5–2	0.5	2	0.5–2	1	2
CSA-44	1–8	4	8	1–8	4	8	1–8	4	8
CSA-138	0.5–4	1	4	0.5–4	1	4	0.5–8	1	4
	Candida krusei (n = 15) *
Amphotericin B	0.5–128	1	4	0.5–256	2	8	0.5–256	2	4
Omiganan	16–256	64	128	32–512	64	128	32–256	128	256
LL-37	16–512	512	512	16–512	512	512	16–512	512	512
CSA-13	0.5–2	2	2	0.5–2	2	2	0.5–8	2	4
CSA-131	0.5	0.5	0.5	0.5	0.5	0.5	0.5–1	0.5	1
CSA-44	0.5–4	1	2	0.5–4	1	2	0.5–4	1	4
CSA-138	0.5–4	0.5	1	0.5–4	0.5	2	0.5–4	1	2
	Candida tropicalis (n = 12)
Amphotericin B	0.5–8	1	4	0.5–16	2	8	0.5–16	2	4
Fluconazole	1–512	2	32	2–512	4	128	2–512	4	128
Omiganan	16–128	32	128	16–256	64	128	32–256	64	128
LL-37	128–512	512	512	128–512	512	512	512	512	512
CSA-13	0.5–2	1	2	0.5–4	1	4	0.5–4	1	4
CSA-131	0.5–1	0.5	1	0.5–1	0.5	1	0.5–2	0.5	1
CSA-44	0.5–2	1	2	0.5–4	1	2	1–2	1	2
CSA-138	0.5–4	0.5	2	0.5–4	1	2	0.5–4	1	2
	Candida glabrata (n = 13)
Amphotericin B	0.5–16	1	4	0.5–16	2	4	0.5–128	2	16
Fluconazole	2–512	128	512	4–512	256	512	4–512	512	512
Omiganan	16–512	256	512	32–512	256	512	64–512	256	512
LL-37	16–512	512	512	64–512	512	512	64–512	512	512
CSA-13	0.5–4	2	4	0.5–4	2	4	0.5–8	2	4
CSA-131	0.5–1	0.5	0.5	0.5–1	0.5	0.5	0.5–4	1	2
CSA-44	0.5–4	1	4	0.5–4	2	4	1–8	2	4
CSA-138	0.5–4	1	4	0.5–4	1	4	0.5–4	1	4

* Candida krusei exhibits natural resistance to fluconazole. MIC/MFC/MBIC values have not been determined.