Table 4.
CRISPR screening database.
| Database | Characteristics | Number of Cell Lines | Usage | Ref. | URL |
|---|---|---|---|---|---|
| DepMap portal | Integrates CRISPR KO screening databases (DepMap, Sanger, and GeCKO) and unifies cellular model (CCLE) and drug sensitivity (PRISM) databases | 786 cell lines 42 cancer types |
Discovering genetic and pharmacological dependenciesPrioritizing tumor contexts and predictive biomarkers Exploring over 2000 cancer models |
[60] | https://depmap.org/portal/ (accessed on 24 Octorber 2021) |
| Project Score | Genetic screens for identifying cancer dependencies | 914 cell lines 25 tissues 7470 fitness genes |
Investigating specific genes, cancer cell models, or tissue types Browsing all gene fitness scores |
[61] | https://score.depmap.sanger.ac.uk/ (accessed on 24 Octorber 2021) |
| PICKLES (Pooled In-Vitro CRISPR Knockout Library Essentiality Screens) | Cell line essentiality profiles for CRISPR KO library and shRNA datasets | More than 50 cell lines for CRISPR screening and 100 cell lines for shRNA library | Easily exploring cell line essentiality and co-essentiality | [62] | http://pickles.hart-lab.org (accessed on 24 Octorber 2021) |
| iCSDB | Integrated DepMap portal and BioGRID ORCS Integrated database of CRISPR-CAS9 screening experiments for human cell lines and clinical information |
976 cell lines | Easily searching for cell line data associated with clinical and molecular data | [63] | https://www.kobic.re.kr/icsdb/ (accessed on 24 Octorber 2021) |
| CRISP-view | Data from 167 studies collected from PubMed, Gene Expression Omnibus (GEO), and Ensemble and Cancer Cell Line Encyclopedia (CCLE) | 321 human samples 825 mouse samples |
Web interface visualizing datasets, allowing the exploration of interesting genes, cell lines, tissues, studies, or conditions | [64] | http://crispview.weililab.org (accessed on 24 Octorber 2021) |