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. 2021 Nov 13;10(11):3152. doi: 10.3390/cells10113152

Figure 6.

Figure 6

Model for the role of miR 208a in regulating mitochondrial function in cardiomyocytes. A decrease in miR 208a expression activates mitochondrial biogenesis via thyroid signaling and derepresses factors that control nuclear transcription, mitochondrial translation, oxidative stress, integrity, and turnover. SNX10, Sortin nexin 10; MED7, mediator complex subunit 7; MRPS28, mitochondrial ribosomal protein S28; STC1, Stanniocalcin 1; TRA, thyroid hormone receptor A; MHCα, myosin heavy chain α; MHCβ, myosin heavy chain β.