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Classification of the reported representative ATX inhibitor types based on binding modes. Left: Schematic diagrams of the binding modes with 3D structures of ATX inhibitor; Right: 2D structures of ATX inhibitor. (A). PF-8380, type I, (ID 5L0K); (B). PAT-078, type II, (ID 4ZG6); (C). TUDCA, type III (ID 5DLW); (D). GLPG-1690, type IV, (ID 5MHP).
