Scheme 3.
Synthesis of 39. Reagents and conditions: (i) iPr2EtN, NMP, 80 °C; (ii) 5N HCl, THF, 50 °C; (iii) 2-chloroacetyl chloride, Et3N, DCM, RT.; (iv) 3-butyn-1-ol, NaH, THF, 0 °C; (v) CuSO4 5H2O, L-sodium ascorbate, TMSN3, DMF, H2O, 90 °C.
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