Table 4.
Compound 43–62.
No. | Structure | Assay | Biological Data | Reference |
---|---|---|---|---|
43 |
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LPC assay | IC50 = 43.6 nM | [77] |
44 |
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LPC assay | IC50 = 57.6 nM | |
45 |
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LPC assay | IC50 = 78.6 nM | |
46 |
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FS-3 assay | IC50 = 21 nM | [78] |
47 |
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FS-3 assay | IC50 = 9 nM | [79] |
48 |
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FS-3 assay | IC50 = 219 nM | [80] |
49 |
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FS-3 assay | IC50 = 218 nM | |
50 |
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LPC assay | IC50 = 472 nM | [81] |
51 |
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LPC assay | IC50 = 20 nM | |
52 |
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LPC assay | IC50 = 26 nM | |
53 |
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LPC assay | IC50 = 0.3 nM | |
54 |
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LPC assay Plasma assay |
IC50 = 2 nM IC50 = 9.7 nM |
[82] |
55 |
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LPC assay Plasma assay |
IC50 = 1.1 nM IC50 = 8.9 nM |
|
56 |
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LPC assay | IC50 < 300 nM | [83] |
57 |
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LPC assay | IC50 = 81 nM | |
58 |
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LPC assay | IC50 = 473 nM | [84] |
59 |
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LPC assay Plasma assay |
IC50 = 1 nM IC50 = 14 nM |
|
60 |
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LPC assay(ewATX) LPC assay(hATX) |
IC50 = 87 nM IC50 = 134 nM |
[84] |
61 |
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LPC assay | IC50 = 10.4 μM | [23] |
62 |
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LPC assay | IC50 = 8.8 μM |