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. Author manuscript; available in PMC: 2021 Nov 26.
Published in final edited form as: Cell Rep. 2020 Nov 17;33(7):108376. doi: 10.1016/j.celrep.2020.108376

Figure 1. Busulfan Chimeric Mice Exhibit Normal Peripheral B Cell Compartments.

Figure 1.

Busulfan chimeras were generated as described in STAR Methods (n = 47) and compared with WT controls (n = 74). Data are pooled from multiple experiments.

(A) Gating strategy to identify transitional, follicular mature, and germinal center B cells.

(B) Comparing the sizes of B cell subsets in WT control mice and busulfan chimeras.

(C) Comparing proliferative activity in WT and busulfan chimeric mice, using Ki67 expression.

(D) Host-derived B cells are gradually replaced by donor-derived cells over time. Scatter derives largely from variation in levels of stable bone marrow chimerism achieved in treated mice.

See also Figure S1.